|
Wolfram Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results reveal a role for IRE1 in preventing a cell death-initializing step that emanates from the ER and provide a potential target for treating diseases characterized by ER stress, including diabetes and Wolfram syndrome.
|
26106220 |
2015 |
|
Virus Diseases
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We found that NDV infection activated all three branches of the UPR signaling (PERK-eIF2α, ATF6, and IRE1α) and triggered apoptosis, in avian cells (DF-1 and CEF) and in various human cancer cell types (HeLa, Cal27, HN13, A549, H1299, Huh7, and HepG2).
|
31767828 |
2019 |
|
Virus Diseases
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo.
|
31086333 |
2019 |
|
Virus Diseases
|
0.050 |
Biomarker
|
group |
BEFREE |
IRE1α promotes viral infection by conferring resistance to apoptosis.
|
28588082 |
2017 |
|
Virus Diseases
|
0.050 |
AlteredExpression
|
group |
BEFREE |
These results suggest that the asynchronous actions of two branches of the unfolded protein response (UPR), namely, IRE1α, and PERK, activated by ER stress resulting from the virus infection, are associated with enhancement or suppression of TNF-α production, respectively.<b>IMPORTANCE</b> The activation of AMϕ is controlled by the microenvironment to deter excessive proinflammatory cytokine responses to microbes that could impair lung function.
|
29070690 |
2018 |
|
Virus Diseases
|
0.050 |
Biomarker
|
group |
BEFREE |
Taken together, our evidence suggests that IRE1α is involved in HSV-1 replication, and its RNase and kinase activities play differential roles during viral infection.
|
28832521 |
2017 |
|
Van der Woude syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, piceatannol reduced the expression of proinflammatory cytokines, including TNF-α, IL-1β and IL-6, the expression of ER stress markers CHOP and phosphorylated-IRE1α, and the generation of oxidative stress in D-GalN/LPS-treated mouse liver.
|
30173053 |
2018 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In this model, two key mechanisms of tumor progression and cancer cell survival are functionally linked to IRE1α.
|
26325176 |
2015 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression.
|
29311133 |
2018 |
|
Tumor Progression
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The activation of the UPR sensor IRE1α has been described to play an important role in tumor progression.
|
22718352 |
2012 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The presence of IRE1α, but not its RNase activity, is therefore required for glioblastoma neovascularization, whereas invasion results only from RNase inhibition.
|
26325176 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We found that knockdown of IRE1α inhibited colon cancer cell migration and invasion in vitro and metastasis in vivo.
|
31326465 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our results also further support the crucial contribution of IRE1α to tumor growth, infiltration and invasion and extend the paradigm of secretome control in tumor microenvironment conditioning.
|
22718352 |
2012 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In comparison, selective invalidation of IRE1α RNase did not compromise tumor angiogenesis but still elicited invasive features and vessel co-option.
|
26325176 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the pro-apoptotic activity of YD277 in TNBC was mediated by the transcription of IRE1α, a key molecule in the endoplasmic reticulum (ER) stress pathway.
|
28740556 |
2017 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the pro-apoptotic activity of YD277 in TNBC was mediated by the transcription of IRE1α, a key molecule in the endoplasmic reticulum (ER) stress pathway.
|
28740556 |
2017 |
|
Systemic cryptococcosis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Nevertheless, both C. deuterogattii ire1Δ and hxl1Δ mutants are avirulent in a murine model of systemic cryptococcosis, suggesting that a non-thermotolerance phenotypic trait also contributes to the role of the UPR pathway in the virulence of pathogenic Cryptococcus species.
|
29802329 |
2018 |
|
Systemic candidiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also uncovered the attenuated virulence of the C. glabrata Δire1 mutant in a mouse model of disseminated candidiasis.
|
23382685 |
2013 |
|
Subarachnoid Hemorrhage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results We found that BI-1 knockdown increased histological injury and the percentages of TUNEL-positive neuron in hippocampal, promoted the expressions of endoplasmic reticulum (ER) stress proteins inositol-requiring enzyme 1α (IRE1α) and TNF receptor-associated factor 2 (TRAF2), and increased the activation levels of apoptosis signal-regulating kinase 1 (ASK1) and c-Jun N-terminal kinase (JNK) in the hippocampus of SAH rats compared with rats in SAH + vehicle group.
|
29334839 |
2018 |
|
Steatohepatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells.
|
29969718 |
2018 |
|
Steatohepatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.
|
25170079 |
2014 |
|
Steatohepatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
IRE1α deficiency exacerbated hepatic steatosis in mice.
|
29764990 |
2018 |
|
Steatohepatitis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Reactivation of XBP1s in mice lacking hepatic IRE1α restores COPII-mediated lipoprotein secretion and reverses the fatty liver and hypolipidemia phenotypes.
|
31123148 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study showed that silencing EGFR increased radiosensitivity of both radiosensitive and radioresistant oropharyngeal squamous cell carcinoma (OSCC) cells by inhibiting ER stress signaling (PERK-eIF2α-GRP94 and IRE1α-XBP1-GRP78).
|
30414263 |
2018 |